The metabolic state of tumor cells contributes to signals that control their proliferation. German biochemist and Nobel Prize laureate Otto H. Warburg observed in the 1920s that tumor cells radically change their metabolism. This process was termed "Warburg Effect," but was neglected until recently by cancer research. The latest results show it is, indeed, of fundamental importance for the development of aggressive tumors. Richard Moriggl and his co-workers have now published in the journal Leukemia how the tumor promoter STAT5 integrates metabolic signals that contribute to oncogenic transformation. Researchers from the VetmeduniVienna, Ludwig Boltzmann Institute for Cancer Research and Meduni Wien may have thus identified a new target to tackle cancer.
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