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Combination treatment targeting glucose in advanced brain cancer shows promising results in preclinical study

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UCLA scientists have discovered a potential combination treatment for glioblastoma, the deadliest form of brain cancer in adults. The three-year study led by David Nathanson, a member of UCLA's Jonsson Comprehensive Cancer Center, found that the drug combination tested in mice disrupts and exploits glucose intake, essentially cutting off the tumor's nutrients and energy supply. This treatment then stimulates cell death pathways—which control the cancer cells' fate—and prevents the glioblastoma from getting bigger.

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